WEBVTT

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So the other day, a friend of mine who had a problem with his knee

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said to me,

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there's nothing that grows back cartilage on the knee, so I'm

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messed up for the good. And I was like,

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you know, I just happen to know about something that you should know about,

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and there's research backing it because now he's super cynical, super frustrated,

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already had surgery

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years ago.

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Did it work? Yeah. It did for a long time, but now it isn't.

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Looking at all kinds of alternatives,

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PRP, controversial,

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may help.

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Couldn't hurt, except your pocketbook, but maybe it helps. You know? Like so

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he

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has an answer now.

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And who is responsible

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in part

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majority for bringing us that? And that is Kiran Krishnan, my very special guest. I'm Siobhan Sarna.

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I'm your host today with chronic condition rescue, SIBO SOS, 12 online summits, the book Healing SIBO.

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And I love to bring to you conversations that are not happening in the typical doctor's office.

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Karan Krishnan

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travels the world

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educating

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other providers. He's a microbiologist.

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I also call him a micro

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microbiomologist.

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Yeah. And he teaches them about the microbiome,

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and he's now

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expanded beyond just cofounding Microbiome Labs into

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taking herbal combinations

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and formulations

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and singles,

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working with their active ingredients,

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and using them for other things that we weren't used to using them for,

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and research based

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goodies.

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Now you can see on his cute shirt, the Biome Learning Center, check that out online because that's one of his new platforms,

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and there's wonderful education there.

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And he's my friend. And so I'm very glad that he's here today.

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I haven't seen him in a while, and we're gonna learn about a very specialized product for

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your

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cartilage,

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the studies, and how it relates to your gut, etcetera. Thank you. Hi, Kieran.

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Hi, Siobhan. So good to be with you. Thank you for having me as well. Thanks for being here. Yeah.

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It's been a while. So

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let's go. We have someone from Johannesburg

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here ready to roll. I saw I saw Australia, Johannesburg,

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Sweden. So we're virtually every corner of the globe. Wow.

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Let me jump in and start sharing my slides.

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And then from there, I'll I'll set the stage for people so they understand.

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Okay. And let me get this into full slideshow

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mode.

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Cool.

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Alright.

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So I'm assuming you can hear I could see the full screen? Yes. We do see yep. Perfect. It's perfect.

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Excellent. Excellent. Well, thank you so much for having me,

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talk about this. So this is a it it's an issue that I think is incredibly important.

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And I think when you look at the data, you'll start to understand why.

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The prevalence

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of joint issues, cartilage degradation

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are mind boggling to me. And they are

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a really, really strong indicator and proxy

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for other dysfunctions that are going on in the body.

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You absolutely feel the dysfunction in the joint more because those joints are load bearing.

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And so you feel the bone and bone rubbing, you feel the tightness, the discomfort, all of that.

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So you realize that the issue is occurring in the joint,

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but that similar issue is occurring elsewhere in the body as well.

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So I'll touch on that and what the connection is between what's happening in the joint and degradative processes throughout the rest of the body.

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And then of course, what is the role of the gut in all of this, right?

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And then finally, we'll talk about the solution. So these are my disclosures.

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Many of you know what those are.

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But a couple of things to keep in mind that leaky gut and inflammatory

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markers that we've we've talked about extensively

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on Siobhan's program and other places, you know, that intestinal permeability leads to chronic systemic inflammation.

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Right? That is the clinical outcome of intestinal permeability.

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It is chronic systemic

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low grade inflammation.

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As a result, individuals with GI problems and GI problems manifest into leaky gut are found to be two times more likely to have osteoarthritis.

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Right?

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So there's a direct connection between what's happening in the gut and an increased risk for developing symptomatic osteoarthritis.

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And I wanna clarify

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symptomatic, you'll see why. Right?

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So keep that in mind when we're talking about this two times, three times, whatever, we're we're talking about symptomatic condition.

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And it'll be important to distinguish why I'm saying symptomatic.

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But when we look at the prevalence rate, by 2040, the prevalence is estimated to grow to seventy eight point four million American adults with osteoarthritis.

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That is symptomatic osteoarthritis.

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Right?

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Adults with arthritis attributable activity limitation that is some degree,

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of limitation, whether it's as as

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limited as enable inability to walk or certainly

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carry any weight and walk down to your mailbox or even bend down and pick up things, that's increasing fifty two percent to thirty four and a half million Americans by by 2040.

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Right now, the

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the 2040

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estimate is seventy eight million Americans.

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I think right now it's somewhere around fifty million American adults have symptomatic joint disease.

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There's also significant overlap with cardiovascular disease. Right? Another inflammatory

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condition.

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Rheumatoid arthritis patients, for example, and rheumatoid and osteoarthritis

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are very similar.

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I'll distinguish them in the upcoming slides, but rheumatoid arthritis patients are two times more likely to develop,

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cardiovascular disease, right? So think about that.

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People with leaky gut, two times more likely to have osteoarthritis.

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People with rheumatoid arthritis, another progressive degenerative joint disease, are two times more likely to develop cardiovascular disease.

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Osteoarthritis

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patients are fifty five, have a fifty five percent increase in, CBD risk compared to non osteoarthritis patients.

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And sixty seven and a half percent of osteoarthritis patients also had hypertension.

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So all of these conditions kind of go together, right? This is true of diabetes and obesity.

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If you're, if you have metabolic syndrome and you're carrying extra weight,

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and it's not just the load bearing with the weight, it's the inflammatory

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processes,

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You're you're almost three and a half times more likely to have osteoarthritis.

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And then people who are diabetic also have increased risk of osteoarthritis, two to three times increased risk.

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So all of this kind of goes together

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under this umbrella of chronic low grade inflammation.

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All of the conditions I just talked about, cardiovascular

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disease, rheumatoid arthritis, osteoarthritis, hypertension,

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you know, obesity, metabolic syndrome, they're all conditions

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of,

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elevated

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chronic low grade inflammation.

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Right? So inflammation is a key here.

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And as we know, leaky gut and intestinal permeability

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becomes

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one of the biggest drivers of chronic low grade inflammation.

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So just to do distinguish between osteoarthritis and rheumatoid arthritis, the big difference, of course, is in rheumatoid arthritis and and maybe you could see my cursor here, but let me grab a little

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pen or laser pointer. I'll do that. Okay.

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Oh, that's a pen.

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Where's my laser pointer?

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I'll probably be pointing at things quite a bit,

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over the next

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over the next few slides. Alright. Maybe I'll just use a pen. That's fine.

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Here we go. Okay.

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So when you look at, rheumatoid arthritis here,

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the the key element with rheumatoid arthritis is there's a definitive

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involvement in your immune cells. Right? So your immune cells

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are are playing a role in active degradation

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of your of your joints and your joint tissue.

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So you've got T cells and B cells and macrophages and all that that have lost tolerance and then are actively attacking your tissue.

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But some of the things that are absolutely

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uniform between rheumatoid arthritis and osteoarthritis

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is the elevation of IL one, IL six, and TNF alpha. In fact, that occurs,

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before some of the immune degradation occurs as well.

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Also the activation of MMPs, which are matrix metalloproteinases

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and ADMTs,

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right? So these are both

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enzymes that actively break down cartilage,

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right?

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So in rheumatoid arthritis, you have enzymes that break down cartilage, you have an elevation of systemic inflammatory markers like IL-one, IL-six, and TNF alpha.

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But then on top of that, you've got your immune system going in there and attacking things.

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In the case of rheumatoid, osteoarthritis,

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you've got the same increase in MMPs,

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ADMTs

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as well, and the same inflammatory markers IL-one, IL-six, and TNF alpha,

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right? So in this case, the,

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the cells, the chondrocytes that are supposed to build cartilage

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are the cells that are actively degrading cartilage,

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Right? And some of the things that drive the rheumatoid side are senescence,

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injury,

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genetics, obesity,

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inflammation, which is the biggest one, and metabolic issues and metabolism

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as well.

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There we go.

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So if you take a look oh, I guess those marks stayed on.

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Sorry for that. Let me let me erase them then.

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Don't want them to remain on. They'll distract from the rest of the slides.

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Okay.

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So when you look at the pro inflammatory mediators, right, in between a healthy knee and an osteoarthritic

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knee, the big thing as you see here in the middle, the pro inflammatory mediators are are driving the process of joint

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degradation and damage. TNF alpha, IL six,

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IL 17, IL 18, and so on, and then the upregulation of MMPs.

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And then the anti inflammatory mediators would be the ones that combat the damage.

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But in the case of osteoarthritis, you have this elevation of the pro inflammatory mediators.

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And these pro inflammatory mediators become the important culprits here in the story,

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because these are the things that are actually changing

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the the the, the biology of the knee from being, one that can build and repair to one that actively degrades.

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Right? And I'll explain that mechanism in a second.

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But also keep in mind that IL six, IL one beta, TNF alpha, those same pro inflammatory mediators that are driving the dysfunction within the knee are the exact same pro inflammatory mediators

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that are significantly

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elevated when you have leaky gut.

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Right? So leaky gut becomes a source of these pro inflammatory mediators.

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Now I mentioned that,

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symptomatic conditions. Right? I said that word a few times.

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The reason I wanted to emphasize that was,

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you know, we're talking about

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somewhere around, you know, thirty, forty percent of adults in The US having symptomatic joint disease.

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There was a study done called the Framingham Joint Study, Framingham osteoarthritis study, where they took 900

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adults ages 50 and higher,

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and they who are asymptomatic. Right?

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So these were specifically people that did not have any joint symptoms.

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And then they did MRIs of their joints, and what they found was that eighty nine percent of them,

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right, eighty nine percent of asymptomatic

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people had

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marked,

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you know, indications of joint disease occurring in at least one, if not more, more than one joint, occurring in their body.

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Typically, it was in the load bearing joints like the hips or the knees, but eighty nine percent of asymptomatic adults.

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Right? So if you think about all when you look at the proportion of all adults

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in The US, you've got somewhere between thirty and forty percent that have symptomatic joint disease, and then you take the remaining sixty percent, right, the remaining sixty percent of those adults that don't have symptomatic joint disease, and almost ninety percent of them have confirmed disease progression

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in their joints, in at least one, if not more than one joint, which means that eventually they will become, symptomatic because this is a progressive

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condition. It doesn't

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simply stop on its own. Right?

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So so when you put all those numbers together, it's the vast majority.

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We're talking about ninety plus percent of all adults

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have confirmed,

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pathology associated with joint degeneration.

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Right? So that is a significant issue. And in fact, it affects women

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even more so than men, especially at a given age.

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So when you look at the menopausal transition in women, when they go from premenopause

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into perimenopause and then into postmenopause,

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you look at the,

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the,

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description of musculoskeletal

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pain,

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in in women at different stages. When you look at premenopause

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to postmenopause,

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it almost doubles

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the the number of women that that complain of muscular skeletal pain doubles between the beginning and the end of that stage.

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Right? And why does it double?

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Because the other thing that occurs as you're entering into perimenopause and going into menopause is you end up getting lower and lower diversity in your gut microbiome and a higher incidence rate of leaky gut.

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As a result of high incidence of leaky gut, women tend to become more inflamed systemically.

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This is part of the reason why bone health becomes compromised during that stage,

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cardiovascular risk goes way up. All of those things start to change.

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A lot of it is due to the changes in the gut microbiome of these women and then the resulting chronic low grade inflammation.

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So imagine that, right, you're going from premenopause

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to postmenopause.

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There is a straight linear

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increase in in musculoskeletal

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pain in these women. Right?

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And that's the last thing women need as they're going through perimenopause and all that.

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It's a difficult enough period. The last thing you need is additional pain to suffer with.

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And then when you look at that menopausal transition period, so when you look at women between the ages of 45 and 64, when you compare women and men, radiographic evidence shows that osteoarthritis

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is three times more common in women than it is in men in that age group.

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And when you look at hospital

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based data, it's a ten to one female to male ratio for osteoarthritis,

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in terms of the the,

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the diagnosis of osteoarthritis,

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which and then and all of that data peaks at around age 50.

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So if we take it take women and men between 40 and 50, you're gonna find 10 more women developing symptomatic osteoarthritis

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than men. And sixty four percent of women with knee knee osteoarthritis

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also

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experience symptom onset during the perimenopausal

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period or within five years of menopause or hysterectomy.

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Right? So so women have a unbalanced

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rate of suffering

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with this issue compared to men. Men suffer a good amount,

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but but women tend to have to deal with it more. And again, as a reminder, intestinal permeability

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leads to chronic systemic inflammation

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and elevation of biomarkers like IL-six, TNF alpha, interleukin-one

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beta, and then individuals with GI problems who are individuals who are marked with intestinal permeability

249
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are found to have two times as likely,

250
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likelihood of having, osteoarthritis.

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Right? So all of it is connected.

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Now let's talk briefly about what's happening here

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in the osteoarthritis site. So you look at the on the left hand side,

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certainly it's my left hand side, so it should be yours as well,

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in the healthy joint, right?

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So you've got these the the subchondral bone, which is the bone that the cartilage is sitting on and attached to.

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You've got the meniscus and then you've got the synovium, which is an important

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that's the space, the physical space

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in the joint,

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and then that joint cavity itself.

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And that synovium is like the fluid that fills the space, the joint cavity is the open space.

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And then the important thing we're looking at here is the articular cartilage, right?

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So keep in mind those physiological

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items. Now, the way osteoarthritis

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starts is it starts with a dysfunction in the subchondral bone.

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As inflammation, as chronic inflammation goes up, you start to get a shift in the subchondral bone,

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where you have osteoclastic

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cells, which are the bone,

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breakdown cells

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starting to proliferate.

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In fact, an increase in inflammation can take the bone building cells, which are osteoblastic cells and make them osteoclastic cells.

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So they initiate

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bone degradation.

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The other thing that occurs as a result of that is the microvasculature,

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which is a circulation

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that the subchondral bone has. Those micro vessels start to collapse and fall apart because

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of the inflammation. So their integrity, their vascular, what we call compliance,

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starts to fall apart. Right?

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So you imagine all these tiny little micro vessels are starting to collapse and fall apart, which means that they're not getting blood supply adequately.

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They're not holding and transferring blood supply the way they should be.

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The problem with that is that the the articular cartilage and this whole synovial space doesn't have its own blood supply.

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It counts on diffusion of blood from the micro vessels in the subchondral bone to diffuse blood into the space and then pull the used blood back out and take it throughout the circulation.

283
00:17:41.080 --> 00:17:44.780
Right? But if your if your subchondral bone is starting to dismantle

284
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and you have, microvasculature

285
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that are starting to fall apart and dismantle,

286
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you're not gonna get adequate circulation

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in that synovial space, in that synovium, that fluid that bathes the the cartilage.

288
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And so what you start to get is an accumulation

289
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of the pro inflammatory mediators

290
00:18:04.205 --> 00:18:10.840
that have leaked into that space, and those pro inflammatory mediators remain in that space and don't get flushed out.

291
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Right?

292
00:18:11.220 --> 00:18:17.800
So now when you have, an increase in pro inflammatory mediators in this space, you're essentially bathing the cartilage

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00:18:18.180 --> 00:18:19.000
in inflammation.

294
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And when you're bathing the cartilage in inflammation, the chondrocytes,

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which are the cells that build the cartilage and put the cartilage on, those chondrocytes shift from being a cell that is anabolic, meaning it is building and repairing cartilage,

296
00:18:33.940 --> 00:18:37.800
into a cell that's catabolic, which is actively degrading the cartilage.

297
00:18:38.100 --> 00:18:40.200
Remember those MMPs and ADMTs?

298
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Those are the enzymes that break down cartilage. Those are being produced

299
00:18:44.420 --> 00:18:51.395
by the chondrocytes, the same cells that are supposed to be building and maintaining your cartilage, right, and has been for the most of your life.

300
00:18:51.695 --> 00:18:54.035
Now because of the presence of that inflammation,

301
00:18:54.655 --> 00:18:59.075
they have switched confirmation and now are actively degrading the tissue.

302
00:18:59.455 --> 00:19:04.195
Right now I mentioned earlier that this occurs in the joint, but it does occur elsewhere.

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00:19:04.530 --> 00:19:08.390
And I mentioned how the joint becomes kind of a canary in the coal mine or,

304
00:19:08.770 --> 00:19:12.630
a signal that that there is a degradative process happening in the body.

305
00:19:13.170 --> 00:19:15.750
Why I say that is because remember, the inflammation

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00:19:16.130 --> 00:19:19.110
that is driving this process is systemic inflammation.

307
00:19:19.645 --> 00:19:24.785
It's not inflammation that is only concentrated in the joint. It's systemic inflammation

308
00:19:25.245 --> 00:19:26.865
as those markers are elevated,

309
00:19:27.325 --> 00:19:33.345
makes its way to all kinds of areas of the body, including subchondral bone and then eventually in the synovium

310
00:19:33.840 --> 00:19:35.460
causing all of this dysfunction.

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00:19:35.840 --> 00:19:55.855
And so if it's causing the dysfunction in the joint and you're starting to feel it, I can guarantee you it's causing the same dysfunction elsewhere in the body because everywhere else in the body, in your brain, in your central nervous system, in your heart, in your cardiac muscles, right, in your skeletal muscles, all of these other areas have similar cells to the to those chondrocytes

312
00:19:56.395 --> 00:20:03.190
that are normally building cells, but because of inflammation, they switch from being building cells to being degrading cells.

313
00:20:03.490 --> 00:20:07.910
Right? And that's occurring in your muscle. This is why muscle loss occurs as people get older.

314
00:20:07.970 --> 00:20:09.170
That's happening in your nerves.

315
00:20:09.170 --> 00:20:13.270
That's why nerve damage occurs and and degradation in the central nervous system.

316
00:20:13.330 --> 00:20:16.125
We start to get brain fog and memory issues and all that.

317
00:20:16.205 --> 00:20:19.585
This is happening at the cellular level in your mitochondria.

318
00:20:19.725 --> 00:20:25.745
This is why energy becomes really difficult to generate and and fatigue and all of that starts to set in.

319
00:20:25.805 --> 00:20:29.025
So what's happening in your joints that you may feel

320
00:20:29.520 --> 00:20:35.060
is an indicator that a similar process is occurring everywhere else in your body as well.

321
00:20:35.200 --> 00:20:38.820
That is the really important thing to remember and to note.

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00:20:39.440 --> 00:20:44.695
And when you think about that Framingham study that showed that eighty nine percent of asymptomatic

323
00:20:44.995 --> 00:20:50.774
people had active joint disease and they just simply didn't feel it yet, meaning the cartilage wasn't degraded

324
00:20:51.634 --> 00:21:00.630
enough to feel it, that means eighty nine percent of adults who have no symptoms yet have degradative processes happening throughout their body.

325
00:21:01.170 --> 00:21:04.370
Right? And all of it is driven by chronic low grade inflammation.

326
00:21:04.370 --> 00:21:06.550
And a lot of that chronic low grade information

327
00:21:07.010 --> 00:21:08.325
is coming from the gut.

328
00:21:08.485 --> 00:21:13.865
And it's no surprise when you know all of that information that I just shared that that osteoarthritis

329
00:21:14.404 --> 00:21:17.945
is the second biggest driver of disability worldwide

330
00:21:18.404 --> 00:21:20.264
according to the World Health Organization.

331
00:21:20.659 --> 00:21:24.760
It's next to cardiovascular disease. Cardiovascular disease is still number one,

332
00:21:25.299 --> 00:21:26.360
but osteoarthritis

333
00:21:26.899 --> 00:21:31.460
is is number two. And remember, cardiovascular disease and osteoarthritis go hand in hand.

334
00:21:31.460 --> 00:21:32.360
If you have osteoarthritis,

335
00:21:32.885 --> 00:21:35.865
you're fifty percent more likely to get cardiovascular disease.

336
00:21:36.245 --> 00:21:41.225
And as a result, having one definitively causes increases for the other.

337
00:21:41.365 --> 00:21:44.265
So the two biggest drivers of disability

338
00:21:44.565 --> 00:21:45.065
worldwide

339
00:21:45.380 --> 00:21:49.320
are driven by the same root cause at chronic low grade inflammation.

340
00:21:50.180 --> 00:21:54.100
Right? So this becomes a big issue. So what can we do about it?

341
00:21:54.100 --> 00:21:56.340
Clearly, it is an important issue, right?

342
00:21:56.340 --> 00:22:06.455
I think all of you can sense that from, you know, no matter what you understood and picked up from the first few slides, I think you're starting to understand that this is a big issue.

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00:22:06.455 --> 00:22:17.570
This is a very prevalent issue, and this is an issue likely going on in your system right now in one place or the other, whether it's a joint, the the nerves, the brain, the heart,

344
00:22:18.110 --> 00:22:19.890
wherever it is, it's occurring.

345
00:22:20.510 --> 00:22:21.650
And if it's occurring,

346
00:22:22.110 --> 00:22:28.125
then you it's progressive, meaning it only it's gonna get worse over time unless you arrest it and you stop it.

347
00:22:28.125 --> 00:22:29.985
Right? So what can we do about it? Well,

348
00:22:31.005 --> 00:22:33.745
we looked at a very straightforward approach

349
00:22:34.125 --> 00:22:36.385
of using plant based nutrition

350
00:22:37.325 --> 00:22:38.865
to to go after

351
00:22:39.325 --> 00:22:39.825
the,

352
00:22:40.445 --> 00:22:41.665
the the inflammatory

353
00:22:42.045 --> 00:22:42.545
mechanism

354
00:22:43.110 --> 00:22:46.970
and slow down that particular inflammatory mechanism, the IL-six,

355
00:22:47.350 --> 00:22:52.809
IL-one, TNF alpha in particular, right? So you have to be able to target those mediators

356
00:22:53.430 --> 00:22:54.650
and then also

357
00:22:55.110 --> 00:22:58.490
inhibit and reduce the expression of those enzymes

358
00:22:59.695 --> 00:23:01.394
that actively degrade the joint.

359
00:23:01.455 --> 00:23:05.554
And then we were even more, you know, optimistic and said maybe we can find,

360
00:23:06.095 --> 00:23:10.735
an an impact on, you know, enzymes that actually help rebuild a joint as well.

361
00:23:10.735 --> 00:23:12.799
So that's why we went to plant based medicine.

362
00:23:13.420 --> 00:23:15.020
You know, plants are very complex.

363
00:23:15.020 --> 00:23:19.580
They have lots of different active ingredients, and so you can get some amazing effects out of plants.

364
00:23:19.580 --> 00:23:30.294
And we isolated a particular type of boswellic acid and celery seed, and then we did all kinds of work, preclinical work on identifying actives within these plants that could potentially

365
00:23:30.914 --> 00:23:35.414
give the effect that we're looking for. And so we've identified 13 synergistic bioactives

366
00:23:35.715 --> 00:23:37.015
that we now standardize

367
00:23:37.875 --> 00:23:38.910
the product to,

368
00:23:39.470 --> 00:23:44.210
and some of them have never really been described or utilized. Like, for example, Serratol.

369
00:23:44.430 --> 00:23:48.450
It's not found in any of the boswellic acid product or celery seed product.

370
00:23:48.990 --> 00:23:54.050
You know, the Bergaptan is is not really described when utilized in any celery seed product.

371
00:23:54.154 --> 00:23:58.174
So we've got a number of active ingredients in this new formulation

372
00:23:58.875 --> 00:24:03.534
that aren't actually found or utilized by by any other source

373
00:24:03.835 --> 00:24:04.894
of of similar,

374
00:24:05.595 --> 00:24:06.654
of similar actives.

375
00:24:07.290 --> 00:24:09.070
All of you have heard of boswellia serratia.

376
00:24:09.290 --> 00:24:13.550
Most of you have heard of apium graviolans, which is a celery seed.

377
00:24:13.850 --> 00:24:17.290
We know that boswellia has this, you know, five,

378
00:24:17.690 --> 00:24:18.590
this lipoxygenase,

379
00:24:20.495 --> 00:24:21.315
which they

380
00:24:21.615 --> 00:24:22.434
term AKBA.

381
00:24:22.735 --> 00:24:25.075
That's a term that you see normally on the labels.

382
00:24:25.615 --> 00:24:30.034
They it is a strong LOX inhibitor, so it has anti inflammatory effects.

383
00:24:30.735 --> 00:24:33.690
But what we were going for is what else does it do? Right?

384
00:24:33.690 --> 00:24:39.389
And we discovered this compound called Serratol in it that actually can induce tissue repair.

385
00:24:39.610 --> 00:24:42.990
And we studied that in a mouse model, where we were,

386
00:24:43.610 --> 00:24:44.110
inducing

387
00:24:44.889 --> 00:24:45.389
gastric

388
00:24:45.815 --> 00:24:50.135
mucosal damage. Right? Specifically, and when I say gastric, so it means the stomach. Right?

389
00:24:50.135 --> 00:24:50.875
So stomach,

390
00:24:51.575 --> 00:24:55.675
mucosal damage, this mimics the, an ulcer like process.

391
00:24:56.455 --> 00:24:57.895
And then we use the,

392
00:24:58.695 --> 00:25:04.250
the Serritol from the boswellia that we had that we've identified and and developed, and the Serritol

393
00:25:04.789 --> 00:25:09.130
compared to control induced repair of those gastric ulcers.

394
00:25:09.510 --> 00:25:13.529
Right? So it plays a role in tissue recovery as well.

395
00:25:13.605 --> 00:25:20.745
And then the APM grabiolins, we have three active ingredients, and I'll show you what those are, but they have both COX and LOX inhibition.

396
00:25:20.804 --> 00:25:22.265
LOX is, of course,

397
00:25:22.725 --> 00:25:23.705
the pro inflammatory,

398
00:25:24.245 --> 00:25:26.825
pathways, and then the COX is a propane pathways.

399
00:25:27.300 --> 00:25:33.480
So this does have an impact in on pain as well if you're feeling it in different parts of your joints.

400
00:25:33.540 --> 00:25:35.300
So these are the active compounds, right?

401
00:25:35.300 --> 00:25:38.920
So these are all all the ones that are left of this yellow dotted line,

402
00:25:39.300 --> 00:25:40.360
or dashed line

403
00:25:41.115 --> 00:25:42.575
are the actives in the boswellia.

404
00:25:42.875 --> 00:25:44.175
You'll see the seritol,

405
00:25:44.875 --> 00:25:45.375
enterichilic

406
00:25:45.755 --> 00:25:46.255
acid.

407
00:25:46.395 --> 00:25:52.155
These are both unique compounds that are unique to our boswellia and not found in anything else.

408
00:25:52.155 --> 00:25:58.870
And then you find the apen and bergaptan are also very unique compounds to this celery seed that are not found in any other products.

409
00:25:58.870 --> 00:26:00.810
And it's this unique combination

410
00:26:01.350 --> 00:26:05.990
that'll give you all the effects that I'm gonna share with you with by looking over the clinical trials.

411
00:26:05.990 --> 00:26:06.405
Right?

412
00:26:07.285 --> 00:26:15.045
So so we wanna take kind of an interventional approach to look at the underlying mechanisms behind the issues around joint health and so on.

413
00:26:15.045 --> 00:26:19.685
And then how can we intervene with these unique compounds and do they intervene? Right?

414
00:26:19.685 --> 00:26:25.120
So keep in mind, we did preclinical studies and all that, and we validated that it likely will have an impact.

415
00:26:25.660 --> 00:26:29.600
And then here are some studies to share with you. The one of the first studies we did

416
00:26:29.900 --> 00:26:34.380
was a nine ninety day study, so three months study with 1,236

417
00:26:34.380 --> 00:26:34.785
subjects.

418
00:26:35.345 --> 00:26:41.025
Right? That is a large, huge number for a supplement study, 1,236.

419
00:26:41.025 --> 00:26:42.785
Now why is that number important to us?

420
00:26:42.785 --> 00:26:55.009
Well, once you get above a certain threshold based on your recruitment, especially if you're recruiting a wide age range, now you're getting population level data because you're getting enough of a sample size of different people.

421
00:26:55.009 --> 00:26:55.330
Right?

422
00:26:55.330 --> 00:27:01.695
You get men, women, different ages, different health statuses, and so on, different medications that they're taking.

423
00:27:01.695 --> 00:27:06.115
So now you're getting a wide variety of of people, which then starts to lend itself

424
00:27:06.495 --> 00:27:09.955
to to looking like a population level study.

425
00:27:10.014 --> 00:27:14.674
Because our goal here was to see, you know, if this product helps with osteoarthritis

426
00:27:15.695 --> 00:27:17.554
symptoms and the issues around that,

427
00:27:18.090 --> 00:27:19.150
and and cartilage,

428
00:27:19.690 --> 00:27:25.790
degenerative issues, does it help only certain categories of people or does it help across the board?

429
00:27:25.850 --> 00:27:29.070
Right? That's a very important thing to to be able to answer.

430
00:27:29.290 --> 00:27:31.690
And and the publication, if you read the study,

431
00:27:32.375 --> 00:27:35.335
shows that it helps across the board. Right?

432
00:27:35.335 --> 00:27:39.195
And so here's what we see is about a seventy five percent reduction

433
00:27:39.655 --> 00:27:45.115
in pain and a very both and this is pain is measured by something called the WOMAC and the VAST scale.

434
00:27:45.770 --> 00:27:50.909
In the WOMAC scale, you also have quality of life, mobility, and a number of other features.

435
00:27:51.130 --> 00:27:55.149
And so when you look at the quality of life improvement, we see about a,

436
00:27:55.450 --> 00:28:00.794
what is it, going from around 40 to around 80, so almost a 50%

437
00:28:00.794 --> 00:28:04.154
increase in quality of life and about a 75%

438
00:28:04.154 --> 00:28:06.255
decrease in pain and immobility,

439
00:28:07.434 --> 00:28:10.715
stiffness and so on. Right? So in a in a nearly,

440
00:28:11.115 --> 00:28:12.554
you know, 1,300

441
00:28:12.554 --> 00:28:14.635
subject study or 1,236

442
00:28:14.635 --> 00:28:15.455
to be precise,

443
00:28:15.850 --> 00:28:16.509
we saw,

444
00:28:16.809 --> 00:28:22.669
a very, very significant reduction in pain, discomfort, and an improvement in mobility as well as a significant

445
00:28:22.970 --> 00:28:24.590
improvement in quality of life.

446
00:28:25.049 --> 00:28:26.990
And on top of that, there were no,

447
00:28:27.529 --> 00:28:31.065
adverse events at all, which is really, really great to see.

448
00:28:31.065 --> 00:28:35.005
So now we know it works across the board in at a population level.

449
00:28:35.305 --> 00:28:40.585
It doesn't matter whether you're male, female, what age you are, what medications you are, any of that stuff.

450
00:28:40.585 --> 00:28:43.805
It seems to work across the board, right, in this study.

451
00:28:44.450 --> 00:28:49.750
Then the next study was looking at what does it do for people who are in who have osteoarthritis.

452
00:28:50.290 --> 00:28:54.690
Oh, and keep in mind, one more thing I should mention. This is in osteoarthritis patients. Right?

453
00:28:54.690 --> 00:29:06.345
These are people who have been diagnosed with symptomatic osteoarthritis has have have had, scans and and radiographs of their knees and clear closing in of the bones and getting close to bone and bone rubbing.

454
00:29:06.345 --> 00:29:09.300
Some of these individuals had osteoarthritis for a decade,

455
00:29:09.940 --> 00:29:12.100
and had cartilage completely gone. Right?

456
00:29:12.100 --> 00:29:16.420
And so the the idea that you can't ever reverse that, you can't regrow the cartilage.

457
00:29:16.420 --> 00:29:21.000
So so all of that is captured in this large population like trial.

458
00:29:21.700 --> 00:29:24.735
The second study was a little more specific to look at,

459
00:29:25.215 --> 00:29:29.075
what we call NSAID sparing effect. Right? So most people who have osteoarthritis,

460
00:29:29.695 --> 00:29:35.934
whether they're on prescription meds or not, they tend to utilize NSAIDs like, you know, Tylenol and sorry.

461
00:29:35.934 --> 00:29:37.554
Not Tylenol, but, ibuprofen.

462
00:29:38.410 --> 00:29:41.630
They use ibuprofen quite a bit because typically

463
00:29:42.330 --> 00:29:42.810
the,

464
00:29:43.370 --> 00:29:48.030
the prescription medication is limited and it doesn't work throughout the entire day.

465
00:29:48.090 --> 00:29:51.230
And so to function to get to sleep and all that, they're using,

466
00:29:51.610 --> 00:29:53.630
NSAIDs every four to six hours.

467
00:29:53.875 --> 00:30:00.054
And and we know that NSAIDs increase the risk of cardiovascular disease and all kinds of other issues and liver damage and so on.

468
00:30:00.195 --> 00:30:05.174
So if they can spare the amount of NSAIDs they're using, then that's a very great thing. Right? So,

469
00:30:05.635 --> 00:30:09.270
in this study, there was almost 400 subjects. They were given the,

470
00:30:10.070 --> 00:30:16.890
the combination of the boswellia and celery seed, and then and then they were looking at pain scoring again, and then they were looking at,

471
00:30:17.270 --> 00:30:19.510
you know, use a utilization of NSAIDs.

472
00:30:19.510 --> 00:30:29.375
And what we found was again a consistent seventy five percent reduction in pain, and then the the use of NSAID declined from seventy percent of the the individuals

473
00:30:29.835 --> 00:30:31.375
using NSAIDs very regularly

474
00:30:31.995 --> 00:30:34.315
down to thirty two percent of the individuals. Right?

475
00:30:34.315 --> 00:30:39.810
So we cut the amount of number, the number of individuals who use NSAIDs regularly in half.

476
00:30:39.950 --> 00:30:44.130
And imagine if you didn't have to be taking NSAIDs all the time just to function,

477
00:30:44.430 --> 00:30:47.870
that is a massive service and it was very exciting to see it.

478
00:30:47.870 --> 00:30:51.735
Then again, like the previous study, no adverse events at all.

479
00:30:52.535 --> 00:30:56.215
The study number three was a much more detailed study. Right?

480
00:30:56.215 --> 00:31:02.635
It was a smaller number of subjects, but we really wanted to dig into the heart of the matter as to what is actually happening

481
00:31:03.015 --> 00:31:05.520
at the joint for these individuals. Right?

482
00:31:06.160 --> 00:31:10.420
So and this was a double blind placebo controlled study, 62 subjects.

483
00:31:10.800 --> 00:31:19.780
We even did radiographs or imaging of the knees, not using that as a standard part of the test, but it definitely shows some very significant and exciting improvements.

484
00:31:20.425 --> 00:31:24.445
So the control group in the study remained the same. Nothing changed. No significant

485
00:31:24.905 --> 00:31:25.405
changes

486
00:31:26.025 --> 00:31:30.765
in any way at all. And and over the ninety days, some of them reported higher pain and dysfunction

487
00:31:31.225 --> 00:31:32.040
in their joints,

488
00:31:32.440 --> 00:31:35.740
but not to a point where you could see it visually

489
00:31:36.040 --> 00:31:39.320
that that the cartilage is present and then it was gone in ninety days. Right?

490
00:31:39.320 --> 00:31:42.060
It's it's a little slower than that in in process.

491
00:31:42.920 --> 00:31:48.975
But what we saw the effects to be for the people in the treatment group was increased joint space.

492
00:31:49.115 --> 00:31:52.335
You'll see some radiographs coming up, in fact, right here,

493
00:31:52.715 --> 00:31:54.735
and we know that when you do a radiograph,

494
00:31:55.115 --> 00:31:58.174
the joint space here is the space that's full of cartilage.

495
00:31:58.620 --> 00:32:02.240
Right? And as you get older, the joint space reduces.

496
00:32:02.620 --> 00:32:03.580
And in this case,

497
00:32:03.900 --> 00:32:05.360
you know, you see it beforehand,

498
00:32:05.900 --> 00:32:07.520
the joint space is virtually,

499
00:32:08.140 --> 00:32:18.365
not even present in in the very front of the knee, right, where you see that almost bone on bone rubbing and certainly from certain angles and movement that will be bone on bone rubbing.

500
00:32:18.365 --> 00:32:19.505
So that'll be excruciatingly

501
00:32:19.885 --> 00:32:20.385
painful.

502
00:32:20.605 --> 00:32:25.890
And then you look at the after, and these are actual cases from the study, you look at the reestablishment

503
00:32:26.430 --> 00:32:30.590
of that joint space. Right? So now the space exists again.

504
00:32:30.590 --> 00:32:36.210
In fact, there's some good data on utilizing joint space as a marker of biological age because

505
00:32:36.510 --> 00:32:40.210
as you age faster, your your biology ages faster,

506
00:32:40.555 --> 00:32:45.135
there's more inflammation and as a result of more inflammation, you get the, chondrocytes,

507
00:32:45.435 --> 00:32:48.415
you know, degrading the the cartilage even faster,

508
00:32:49.515 --> 00:32:51.915
thereby shrinking the joint space, right?

509
00:32:51.915 --> 00:33:04.000
So being able to see that this joint space has gone from virtually nothing on and and then with bone on bone rubbing in one area to this huge increase in joint space, that is really exciting and telling, right?

510
00:33:04.000 --> 00:33:09.140
So we saw overall significant reduction in inflammation, a significant reduction in,

511
00:33:09.995 --> 00:33:15.534
in cartilage degradation markers and a significant increase in cartilage regeneration markers.

512
00:33:15.835 --> 00:33:17.934
There weren't any real changes on

513
00:33:18.235 --> 00:33:19.195
on many of the other,

514
00:33:19.914 --> 00:33:26.350
biomarkers that we looked at, but we did see a measurable decrease in GI symptoms as well. So,

515
00:33:27.289 --> 00:33:31.390
give you more information here. We also looked at things like the six minute walk test.

516
00:33:31.770 --> 00:33:35.710
The six minute walk test is a very good definitive test to look at your

517
00:33:36.034 --> 00:33:37.095
mobility functionality,

518
00:33:37.794 --> 00:33:39.895
you know, VO two max,

519
00:33:40.755 --> 00:33:41.975
aging progression.

520
00:33:42.355 --> 00:33:46.215
You know, basically, pick a straight line, you know, as straight as it can be,

521
00:33:47.075 --> 00:33:51.640
and and without hills or any significant, you know, topography changes,

522
00:33:52.260 --> 00:33:58.180
and then walk straight for six minutes at a very brisk pace, not not while you're running.

523
00:33:58.180 --> 00:34:03.585
You don't you don't wanna end up running, but you walk straight for six minutes and you see how much distance you covered.

524
00:34:04.304 --> 00:34:08.565
And and the more distance you can cover, the fitter and the healthier and the longer you'll live.

525
00:34:08.705 --> 00:34:10.705
That's what the studies are indicating. Right?

526
00:34:10.705 --> 00:34:18.650
So we we looked at the six minute walk test because to us, if we're we're improving the mobility of people, they should be able to have that kind of improvement.

527
00:34:18.650 --> 00:34:21.309
Right? So let's look at all of the changes that occurred,

528
00:34:21.929 --> 00:34:27.449
where the blue is, of course, the placebo group, and the the orange is the is the, cardigenics group.

529
00:34:27.449 --> 00:34:30.809
When you look at IL six, almost a 67%

530
00:34:30.809 --> 00:34:32.589
reduction. Right? That's one of those

531
00:34:32.915 --> 00:34:34.054
systemic quintessential,

532
00:34:35.074 --> 00:34:36.534
pro inflammatory mediator.

533
00:34:36.915 --> 00:34:40.514
Also, a lot of that inflammation of IL six comes from the gut, right? So,

534
00:34:40.915 --> 00:34:45.815
things are modulating in gut. IL one is a very significant pro inflammatory mediator.

535
00:34:46.290 --> 00:34:47.810
That's down 31%.

536
00:34:47.810 --> 00:34:49.750
TNF alpha is down 30%.

537
00:34:50.050 --> 00:34:52.310
And then it's exciting to see that the other

538
00:34:53.250 --> 00:35:05.655
pro inflammatory mediators also were changed, like IL seven and h s c r p, which is really interesting because h s c r p is a great marker for everything from cardiovascular health to Alzheimer's and so on.

539
00:35:05.655 --> 00:35:09.435
It's kind of looking at a global, level of inflammation in the body.

540
00:35:09.575 --> 00:35:14.250
And then, ESR is erythrocyte sedimentation rate. It's an indication

541
00:35:14.630 --> 00:35:17.370
of what kind of inflammation you may have.

542
00:35:17.830 --> 00:35:23.290
If your ESR is is very poor, then it can indicate a autoimmune like inflammatory

543
00:35:23.910 --> 00:35:29.195
response. But as you can see, all of these inflammatory markers came down very significantly

544
00:35:29.895 --> 00:35:31.575
with using the cartogenics. Right?

545
00:35:31.575 --> 00:35:36.315
So we know that it's anti inflammatory and the anti inflammatory component is powerful.

546
00:35:36.695 --> 00:35:39.255
Then we started looking at, well, what's happening with the cartilage?

547
00:35:39.255 --> 00:35:40.940
So you looked at cartilage regeneration

548
00:35:41.480 --> 00:35:41.980
markers,

549
00:35:42.280 --> 00:35:44.619
which is P2A and P and P2CP.

550
00:35:45.320 --> 00:35:47.500
You start to see that the cartogenics,

551
00:35:48.280 --> 00:35:51.900
group has a very significant more than tenfold,

552
00:35:52.535 --> 00:35:53.435
closer twentyfold

553
00:35:54.055 --> 00:35:54.555
increase

554
00:35:54.935 --> 00:35:55.735
in cartilage,

555
00:35:56.215 --> 00:35:57.435
regeneration markers.

556
00:35:57.655 --> 00:36:08.569
At the same time, when you look at the cartilage degeneration markers, you see a significant drop between anywhere from, you know, 30% virtually to or twenty percent virtually to around forty one

557
00:36:08.950 --> 00:36:13.049
percent. There's a significant drop in all of the markers that are indicative

558
00:36:13.589 --> 00:36:16.970
of cartilage degeneration. So imagine that your degenerative

559
00:36:17.349 --> 00:36:20.235
activity is dropping down by thirty, forty percent.

560
00:36:20.315 --> 00:36:23.695
Your regenerative activity is bumping up by forty percent.

561
00:36:23.995 --> 00:36:34.655
That shift that's happening in your joint is what's leading to the repair of the cartilage and regeneration of the cartilage even in people who are in the study that were quite elderly.

562
00:36:34.910 --> 00:36:38.110
Now with all of that, you want to see that the six minute walk test improved, right?

563
00:36:38.110 --> 00:36:42.850
So sure enough, you see here the intervention group, which is the cardi cardiogenic group,

564
00:36:43.230 --> 00:36:45.310
versus the yellow, the placebo group.

565
00:36:45.310 --> 00:36:49.890
At day zero, you know, they they they were basically at the same distance covered

566
00:36:50.615 --> 00:36:55.515
in that six minute walk test. At day seven in itself, you start to see a little deviation

567
00:36:56.055 --> 00:37:00.075
where the treatment group starting is starting to walk a little bit further.

568
00:37:00.135 --> 00:37:05.200
And then by day 15, you get a significant jump in how far how much farther they walk.

569
00:37:05.200 --> 00:37:07.060
And then, of course, that goes up linearly

570
00:37:07.360 --> 00:37:10.660
all the way to day 90, and you get a very significant difference,

571
00:37:11.280 --> 00:37:13.120
in in the distances covered. Right?

572
00:37:13.120 --> 00:37:19.115
So that is showing the functional benefit of of dealing with the joint issues. You can walk farther.

573
00:37:19.115 --> 00:37:20.395
You have more endurance. Right?

574
00:37:20.395 --> 00:37:26.015
You have the ability then to to help yourself stay fit by exercising, by walking, by

575
00:37:26.555 --> 00:37:28.155
jogging. Hopefully, you don't need to jog.

576
00:37:28.155 --> 00:37:31.835
You you probably hurt your knees, but, you know, bike riding and so on. Right?

577
00:37:31.835 --> 00:37:40.340
So all of this is is in developed into this idea that we're shifting the metabolic profile in the body by reducing that chronic inflammation.

578
00:37:41.360 --> 00:37:49.460
And as you reduce the chronic inflammation, you also shift back those chondrocytes from being a catabolic cell, which is degrading the joint

579
00:37:49.815 --> 00:37:53.915
back to the anabolic cell, which is not only not degrading, but actually,

580
00:37:54.535 --> 00:37:56.375
actively rebuilding the joint, right?

581
00:37:56.375 --> 00:38:02.795
So when you look at the clinical outcomes, within about fifteen days, most people saw enhanced physical function,

582
00:38:03.330 --> 00:38:13.650
reduced stiffness and improvement in pain, but a lot of the pain data actually came from day seven, from day seven onwards, people started feeling a significant reduction in pain.

583
00:38:13.650 --> 00:38:16.065
And then when you look at those x rays that I shared,

584
00:38:16.785 --> 00:38:20.484
the x rays revealed an increase in knee joint space

585
00:38:20.785 --> 00:38:32.790
after ninety days of treatment, which is again very significant because that indicates that we're regrowing the cartilage and that's of course supported by the cartilage regeneration markers and the decline in degeneration markers.

586
00:38:33.090 --> 00:38:37.590
We also saw across the board decrease in inflammation, which is good for everything

587
00:38:38.050 --> 00:38:38.610
in the body.

588
00:38:38.610 --> 00:38:47.145
And we saw this cartilage degeneration markers decrease, increase regeneration markers, and a hundred percent of patients reduce GI symptoms, right?

589
00:38:47.145 --> 00:38:53.484
When you surveyed them to ask them about what things they felt, a hundred percent of them reported in that

590
00:38:54.184 --> 00:38:58.684
they got improvement in their GI symptoms. And of course, given that these are osteoarthritic

591
00:38:58.984 --> 00:39:00.260
patients, it's no

592
00:39:00.720 --> 00:39:05.460
surprise that virtually all of them have GI issues, right? That connection we talked about earlier.

593
00:39:05.920 --> 00:39:10.580
We saw an increase in distance covered by six minute walk test. We saw the reduction in fatigue,

594
00:39:10.880 --> 00:39:15.460
long lasting effect after stopping the treatment as well. This is another important point.

595
00:39:15.545 --> 00:39:16.365
So this study

596
00:39:17.065 --> 00:39:21.305
inevitably became a head to head study on with prescription drugs, right?

597
00:39:21.305 --> 00:39:23.885
And the prescription drug in this case was celecoxib,

598
00:39:24.585 --> 00:39:29.670
which is a widely used, you know, opioid based pain killer, right?

599
00:39:29.910 --> 00:39:32.490
And people typically on osteoarthritis are using

600
00:39:33.030 --> 00:39:34.170
celecoxib regularly

601
00:39:34.550 --> 00:39:38.490
on top of the NSAIDs that they use just to function on a day to day basis.

602
00:39:38.630 --> 00:39:40.970
Now, given that the study was being done in osteoarthritis

603
00:39:41.270 --> 00:39:43.865
patients, there's a requirement from the Institutional

604
00:39:44.325 --> 00:39:45.625
Review Board, the IRB,

605
00:39:46.245 --> 00:39:51.865
that if subjects come in, and, of course, the IRB doesn't know who's on which group and neither the researchers,

606
00:39:52.485 --> 00:39:53.865
because it is double blinded.

607
00:39:54.620 --> 00:39:57.760
But the directive is if sub if subjects come in,

608
00:39:58.540 --> 00:40:07.920
for a visit, say it's day seven, day 15, whatever day it is, and they complain that their pain is too much, they are the researchers are obligated to put them on

609
00:40:08.285 --> 00:40:08.945
a prescription

610
00:40:09.245 --> 00:40:11.185
pain medication in this case, celecoxib,

611
00:40:11.645 --> 00:40:15.805
200 mg twice a day, right? So that's what they were they were told to do.

612
00:40:15.805 --> 00:40:17.985
Now what's fascinating about this

613
00:40:18.445 --> 00:40:19.185
is that,

614
00:40:19.805 --> 00:40:20.305
virtually

615
00:40:21.030 --> 00:40:22.810
eighty to ninety percent

616
00:40:23.510 --> 00:40:28.090
of all of the participants in the placebo group who did not know they were in placebo group,

617
00:40:28.710 --> 00:40:34.490
by halfway or three quarters through the study were already back on their prescription pain medication

618
00:40:34.865 --> 00:40:38.085
because, of course, they're taking a placebo. There's no there's no effect

619
00:40:38.385 --> 00:40:43.684
there, and so they were starting to experience too much pain. Right? So for at least half the study,

620
00:40:44.065 --> 00:40:45.684
we had head to head data

621
00:40:46.065 --> 00:40:53.810
between the, between the placebo group who is now back on prescription pain medications and the treatment group who is simply on cardigenics.

622
00:40:54.270 --> 00:40:58.370
And when you look at the data on pain, on mobility, on WOMAC,

623
00:40:58.750 --> 00:41:00.610
quality of life score, on inflammation,

624
00:41:02.045 --> 00:41:06.865
The group, the placebo group that was actually on prescription pain meds saw no improvement

625
00:41:07.325 --> 00:41:15.345
in pain, no improvement in mobility, no improvement in the six minute walk test, no improvement in the in the inflammatory markers, no improvement

626
00:41:15.690 --> 00:41:20.650
in degeneration or regeneration markers of the cartilage. All of those lines are flat lines. Right?

627
00:41:20.650 --> 00:41:23.630
Versus in the cardigenics group, you saw all of the the,

628
00:41:24.730 --> 00:41:28.190
improvements that I I shared with you, which means that for half the trial,

629
00:41:28.825 --> 00:41:34.845
Cardigenics was going head to head with celecoxib, and celecoxib did not move the needle on any of those symptoms.

630
00:41:34.905 --> 00:41:43.290
And this has been long known for people in this space, in in the medical community as well that these pain medications aren't necessarily helping at all because

631
00:41:43.690 --> 00:41:51.390
at best they're trying, they're attempting to mask the pain, but it does nothing for the origin of the pain and the root cause of the pain, right?

632
00:41:51.930 --> 00:41:55.710
Why we're so different here with this is that we're actually tackling

633
00:41:56.375 --> 00:42:00.635
the root cause driver of the pain itself. That's a chronic low grade inflammation

634
00:42:01.015 --> 00:42:07.175
and the shift in the joint from from chondrocytes being rebuilding cells to degrading cells. Right?

635
00:42:07.175 --> 00:42:09.115
So, we're we're we're

636
00:42:09.549 --> 00:42:12.289
reversing that that process and giving people,

637
00:42:13.630 --> 00:42:17.010
results that that last and results that they will feel,

638
00:42:17.789 --> 00:42:23.170
very definitively in a relatively short amount of time and then hopefully the rest of their life as well.

639
00:42:23.285 --> 00:42:26.105
Now that I mentioned that subchondral bone and the microvasculature.

640
00:42:26.485 --> 00:42:32.505
Right? So there is this issue in the early stages of decreased bone perfusion and the physiological

641
00:42:32.805 --> 00:42:34.745
squalae that is associated

642
00:42:35.125 --> 00:42:36.185
with this osteoarthritis,

643
00:42:36.565 --> 00:42:41.290
and and a big part of it is vascular disease and vascular non compliance,

644
00:42:41.750 --> 00:42:43.210
right? So those are the microvasculature

645
00:42:43.750 --> 00:42:45.290
in the subchondral bone.

646
00:42:45.350 --> 00:42:51.110
So one of the things that could be extremely beneficial is utilizing a nitric oxide product, right?

647
00:42:51.110 --> 00:42:53.690
So Calroy has a nitric oxide product called Vasconox.

648
00:42:54.165 --> 00:42:55.625
It improves microvascular

649
00:42:56.005 --> 00:42:59.145
function. It helps rebuild the internal lining

650
00:42:59.445 --> 00:43:01.705
of these vessels called the endothelium,

651
00:43:02.405 --> 00:43:04.165
and then that regenerates and helps,

652
00:43:04.645 --> 00:43:05.145
restabilize

653
00:43:05.845 --> 00:43:06.425
the vessels.

654
00:43:07.480 --> 00:43:07.980
Here's

655
00:43:08.440 --> 00:43:10.600
an overall view on what's happening.

656
00:43:10.600 --> 00:43:14.460
I mentioned many times that there are these building cells like chondrocytes,

657
00:43:15.320 --> 00:43:15.820
and,

658
00:43:16.360 --> 00:43:19.725
and, you know, in your muscles, you have them, in your heart, you have them and all that.

659
00:43:19.805 --> 00:43:23.185
And with enough inflammation, they go from building to degeneration.

660
00:43:23.725 --> 00:43:25.665
So that's called catabolic processes.

661
00:43:25.885 --> 00:43:31.485
And so they're going from anabolic state, which is what they're doing for most of your life, to active catabolic state.

662
00:43:31.485 --> 00:43:33.505
And this is one of the best descriptions

663
00:43:33.965 --> 00:43:34.705
of aging.

664
00:43:35.090 --> 00:43:38.710
Aging is a battle between your catabolic and anabolic systems.

665
00:43:38.850 --> 00:43:44.630
And when the catabolic systems start to win, you start to see the symptoms of aging and you start to accelerate

666
00:43:45.010 --> 00:43:48.310
the symptoms of aging. And all of that is driven by inflammation.

667
00:43:48.785 --> 00:43:52.085
We've shown with this product that we can not only stop the inflammation,

668
00:43:52.785 --> 00:43:55.925
but we can also then reverse the effect of the inflammation.

669
00:43:56.225 --> 00:44:02.005
And keep in mind, eighty nine percent of adults have this going on in their system and they don't even know it.

670
00:44:02.065 --> 00:44:03.050
Right? So

671
00:44:03.430 --> 00:44:08.470
we'll end with that. Well, here we are. Left a few minutes for q and a. Yeah. Holy smokes.

672
00:44:08.470 --> 00:44:13.850
Did anyone just learn something new and having some moments? Pop it into the chat because

673
00:44:14.230 --> 00:44:16.410
I think it helps to reinforce

674
00:44:16.790 --> 00:44:21.395
what you just learned. Like, that was great. Thank you so much as always. My pleasure.

675
00:44:21.775 --> 00:44:24.515
Put some love into the chat for Kieran for sure.

676
00:44:25.615 --> 00:44:30.915
Okay. We have a limited time. I literally will be turning this thing off in thirteen minutes.

677
00:44:31.135 --> 00:44:32.915
Kieran, we have 18 questions.

678
00:44:33.890 --> 00:44:38.470
Let us see the feel free to say yes or no to some of them. Okay. Yes.

679
00:44:38.770 --> 00:44:43.730
Dirk, yours is so complex, and you had a chance last night to ask the really complicated ones.

680
00:44:43.730 --> 00:44:47.175
I'm gonna ask the less complicated one. And if we have time, I'll circle back.

681
00:44:47.655 --> 00:44:53.975
I have heard it said that commensal bacteria in the gut produce metabolites that both train the immune system and help modulate it.

682
00:44:53.975 --> 00:44:57.115
What does this mean precisely, and what is happening here at a micro level?

683
00:44:57.975 --> 00:45:00.455
Yeah. So that that is separate from from,

684
00:45:00.789 --> 00:45:08.490
the mechanisms we talked about today, but it's absolutely true that there are microbes in the gut that produce metabolites that can induce immune proliferation

685
00:45:09.269 --> 00:45:11.769
or can inhibit immune proliferation. Right?

686
00:45:12.230 --> 00:45:18.155
And and more so than that, the the microbes themselves have an influence on the immune system.

687
00:45:18.454 --> 00:45:23.515
And so when you have a healthy diverse microbiome, what you tend to get is an appropriately

688
00:45:23.895 --> 00:45:25.515
trained and and upregulated

689
00:45:25.895 --> 00:45:30.510
and balanced immune response. When you have a dysfunctional microbiome with low diversity,

690
00:45:30.810 --> 00:45:33.050
you miss some of that training. You miss some of that,

691
00:45:33.450 --> 00:45:39.150
that, activation, if you will, or rebalancing so your immune system is confused and attacks everything.

692
00:45:39.609 --> 00:45:40.109
Okay.

693
00:45:41.525 --> 00:45:42.025
Y'all,

694
00:45:42.325 --> 00:45:43.785
I put the link

695
00:45:44.165 --> 00:45:48.025
for the special that they developed just for us in the chat.

696
00:45:48.245 --> 00:45:51.945
And look at the page because you can get up to 15%

697
00:45:52.005 --> 00:45:56.550
off when you click the link, which wasn't working, but it was working. I put an extra

698
00:45:57.090 --> 00:45:57.910
letter in there,

699
00:45:58.290 --> 00:46:00.710
or number or something. So check it out. Also,

700
00:46:02.369 --> 00:46:03.750
and we'll resume the card.

701
00:46:04.850 --> 00:46:09.085
Okay. Dear dear Karen, from all the empire of your products,

702
00:46:09.785 --> 00:46:12.525
what is your approach to positive anti lavingulin,

703
00:46:13.065 --> 00:46:13.565
CDT

704
00:46:13.945 --> 00:46:14.445
BT,

705
00:46:14.825 --> 00:46:17.880
you know what it is, to deal with motility issues,

706
00:46:18.440 --> 00:46:24.460
the antibodies that doctor Pimentel from MAST, from Cedars Sinai found that exist from food poisoning.

707
00:46:24.599 --> 00:46:26.299
You know, he is working on that

708
00:46:27.000 --> 00:46:31.420
at Cedars Sinai. Do you have any suggestions for that that anti

709
00:46:31.880 --> 00:46:32.940
antibody issue?

710
00:46:33.435 --> 00:46:38.315
Yeah. I mean, no. That that that's quite specific for people that that end up with with,

711
00:46:38.715 --> 00:46:39.855
with food poisoning.

712
00:46:39.995 --> 00:46:45.195
And there is no natural compound that I know of or can think of that that deals with that directly.

713
00:46:45.195 --> 00:46:49.440
I mean, I think your best shot is continuing to try to trigger the prokinetic

714
00:46:49.820 --> 00:46:51.680
response from the brain to the gut.

715
00:46:51.820 --> 00:46:56.880
So anything you can do to improve the gut brain communication, like, diversifying your microbiome,

716
00:46:57.180 --> 00:46:57.680
increasing

717
00:46:57.980 --> 00:46:59.680
short chain fatty acid production,

718
00:47:00.474 --> 00:47:04.655
you know, competing out some of the dysfunctional gram negative bacteria in the small intestine.

719
00:47:04.795 --> 00:47:06.895
So using the spore based probiotics,

720
00:47:07.195 --> 00:47:10.474
using some prebiotics, if you can tolerate them, and so on.

721
00:47:10.474 --> 00:47:14.175
All of that will help and work towards it. But for those antibodies,

722
00:47:14.795 --> 00:47:17.390
there's a natural comp, and I'm guessing,

723
00:47:18.089 --> 00:47:23.790
Doctor. Pimentel is working on a drug for that. Yeah. How long would one need to take

724
00:47:24.410 --> 00:47:24.910
cartagenics?

725
00:47:26.089 --> 00:47:28.190
So the way the studies worked,

726
00:47:28.730 --> 00:47:33.865
as you see, most people feel a difference in the pain and mobility within the first seven days.

727
00:47:34.005 --> 00:47:36.505
At fifteen days, you feel a very definitive difference.

728
00:47:37.205 --> 00:47:42.345
The studies were ninety days and at ninety days, you saw about a seventy five percent reduction in pain

729
00:47:42.800 --> 00:47:44.100
in most people and

730
00:47:44.480 --> 00:47:47.940
in almost a doubling in mobility when you look at the six minute walk test.

731
00:47:48.400 --> 00:47:49.780
And then we stopped

732
00:47:50.480 --> 00:47:54.100
the use of the product and then followed people for another thirty days after that.

733
00:47:54.560 --> 00:47:55.940
Ninety percent of the cardigenics

734
00:47:56.415 --> 00:48:02.595
subjects after thirty days of stopping still had complete relief and alleviation of pain and all that.

735
00:48:02.735 --> 00:48:06.335
So so it is it does work long term, even when you stop it.

736
00:48:06.335 --> 00:48:11.955
My recommendation is take it till your your your pain is subsided and you're you're back to having

737
00:48:12.390 --> 00:48:14.950
a good amount of mobility and then go on a maintenance dose.

738
00:48:14.950 --> 00:48:19.049
Take it every two or three days at that point and just maintain it.

739
00:48:19.349 --> 00:48:20.069
Hi, Michael.

740
00:48:20.069 --> 00:48:27.015
Are the benefits of this cumulative after taking it for ninety days or longer periods of time if they stop taking it and don't so he just said yes.

741
00:48:27.095 --> 00:48:29.994
And how does the age of the person consuming the supplement

742
00:48:30.295 --> 00:48:33.994
affect the rate of regrowth and sustained change if they discontinue consumption?

743
00:48:34.214 --> 00:48:35.755
I guess you guys are also smart.

744
00:48:36.135 --> 00:48:37.654
Yeah. Yeah. So that's a great question.

745
00:48:37.654 --> 00:48:45.579
And and we saw when you look at the the the data and you stratify the data by age, what you see is that the oldest individuals

746
00:48:46.280 --> 00:48:50.920
have significant improvement, but the rate of improvement is slower than the younger individuals.

747
00:48:50.920 --> 00:48:51.160
Right?

748
00:48:51.160 --> 00:48:59.855
So an 80 year old will certainly improve at a slower rate than a 60 year old in part because they they have just so much more damage at that point.

749
00:49:00.154 --> 00:49:03.055
Right? But the good news is that that they do improve.

750
00:49:03.434 --> 00:49:07.355
My recommendation to people, this is why I do it. I don't have any joint pain.

751
00:49:07.355 --> 00:49:08.734
I don't have any symptomatic

752
00:49:09.700 --> 00:49:10.200
disease

753
00:49:10.900 --> 00:49:11.480
or condition,

754
00:49:12.100 --> 00:49:16.980
but I know given the Framingham study that I have active joint disease going on, right?

755
00:49:16.980 --> 00:49:17.880
There's likely

756
00:49:18.260 --> 00:49:25.545
no doubt, now maybe less for me because I've been working on the leaky gut side of things for a long time and all that, but I take this prophylactically,

757
00:49:27.365 --> 00:49:30.885
as a way so that I don't ever have to have a joint issue, right?

758
00:49:30.885 --> 00:49:35.925
I don't want to be 55 and all of a sudden my knees are hurting and I can't cycle anymore.

759
00:49:35.925 --> 00:49:39.140
I can't hike anymore and all that. That. That's

760
00:49:39.599 --> 00:49:42.900
the, to me, like the worst part of aging, you know, is loss of functionality.

761
00:49:43.440 --> 00:49:44.500
So I take it prophylactically.

762
00:49:44.720 --> 00:49:50.900
Now I'll tell you this, ever since starting it, I've been measuring my hs CRP, and if anyone knows about hs CRP,

763
00:49:51.280 --> 00:49:55.455
you want to be at one or below, right? Above one means you have too much inflammation

764
00:49:56.235 --> 00:49:58.495
and people are regularly in the six or sevens.

765
00:49:59.275 --> 00:50:05.535
My hs CRP, when, before I started the cartogenics, was around 0.8 or 0.9, so it was already good.

766
00:50:05.690 --> 00:50:10.270
I just got the test done last week with function health and it's down to like 0.5.

767
00:50:10.730 --> 00:50:14.750
So my overall inflammation has cut down by almost 40%

768
00:50:15.050 --> 00:50:17.950
and I attribute a lot of that to this product.

769
00:50:18.655 --> 00:50:21.615
Excellent. Oh, and and beta glucan. I've been taking beta glucan as well.

770
00:50:21.615 --> 00:50:24.435
That's probably helped as well. But this product specifically,

771
00:50:24.815 --> 00:50:29.475
because we have data on HSCRP on this, so that probably was driven a lot by this.

772
00:50:29.695 --> 00:50:30.835
Any drug interactions?

773
00:50:32.079 --> 00:50:32.880
None at all.

774
00:50:33.040 --> 00:50:41.119
That's part of the, you know, one thousand two hundred and sixty eight patient study is that they're on all kinds of stuff, and there were no adverse event, no interactions, and all that.

775
00:50:41.119 --> 00:50:45.380
But, of course, always check with your doctor if you're on array of prescription medications.

776
00:50:45.839 --> 00:50:46.575
Hi, Simon.

777
00:50:46.575 --> 00:50:53.955
Can you use this product for an acute knee injury, tendon, ligament, fascia, four weeks in, but do not want to stop beneficial inflammation?

778
00:50:54.335 --> 00:50:57.295
Great nuance. Yeah. Great great question.

779
00:50:57.855 --> 00:50:59.715
Yes. Inflammation can be extremely beneficial. We have found that with acute injuries, it can help.

780
00:51:00.250 --> 00:51:03.790
We have found that with acute injuries, it can help.

781
00:51:06.330 --> 00:51:11.230
Part of it will be what your age is. So if you're in your 20s, mid-20s

782
00:51:12.090 --> 00:51:13.150
or early 30s,

783
00:51:13.505 --> 00:51:15.925
maybe wait a little bit longer. And if your inflammation

784
00:51:16.225 --> 00:51:18.005
persists after two to three weeks,

785
00:51:18.865 --> 00:51:23.285
you know, then maybe start to take the product so that you can accelerate some of the healing process,

786
00:51:23.905 --> 00:51:27.285
because some of that acute inflammation should be well gone by that point.

787
00:51:27.860 --> 00:51:33.060
But if you're in your 40s and 50s, I would absolutely start on it because the net inflammation is going to be high.

788
00:51:33.060 --> 00:51:36.680
Oh, okay. Well, in that case, Simon. Yeah. It is okay.

789
00:51:37.220 --> 00:51:39.160
You are in your 20s at some point.

790
00:51:40.435 --> 00:51:43.734
But yes, at at 73, I would absolutely take it because

791
00:51:44.194 --> 00:51:46.435
you want a balancing of inflammation, right?

792
00:51:46.435 --> 00:51:51.255
You don't want the IL six, the IL one TNF alpha inflammation.

793
00:51:51.395 --> 00:51:55.420
There are different types of inflammation that help heal. Those are the the,

794
00:51:55.980 --> 00:51:57.680
the arachidonic acid process.

795
00:51:57.980 --> 00:51:58.480
Okay.

796
00:51:59.660 --> 00:52:02.220
There so I'm gonna take everybody in the last few minutes.

797
00:52:02.220 --> 00:52:05.440
I'm sorry we couldn't get to everybody's questions today. You know, I usually

798
00:52:05.820 --> 00:52:07.185
fight like crazy for that,

799
00:52:07.585 --> 00:52:09.185
but we just ran out of time.

800
00:52:09.185 --> 00:52:13.025
And I'm really glad that you told us everything you just told us, Karen, so thank you.

801
00:52:13.025 --> 00:52:16.165
Here's what the page looks like. It's got my little face on there,

802
00:52:16.465 --> 00:52:23.290
and this is an introductory offer. So one bottle is what it is, three pack, 12 pack. You can

803
00:52:23.590 --> 00:52:26.330
see how you're saving on each one of the packs,

804
00:52:27.670 --> 00:52:32.650
and it's saving an additional 10% on the three pack. You've got free shipping in The US,

805
00:52:32.950 --> 00:52:39.015
and you even have a ninety day satisfaction guarantee, which is really unheard of, and I love that you're doing that.

806
00:52:39.015 --> 00:52:42.715
So thank you. You can feel free to add some of their all other proprietary,

807
00:52:43.735 --> 00:52:47.255
excellent products. You see that nitric oxide? Vasconox is a nitric oxide product. Yeah.

808
00:52:47.255 --> 00:52:49.415
That's what you were talking about. Yeah.

809
00:52:49.975 --> 00:52:50.475
So

810
00:52:50.820 --> 00:52:51.560
that being

811
00:52:52.100 --> 00:52:57.640
said, please do take advantage of this. It's not a forever thing. It is a

812
00:52:58.100 --> 00:52:59.080
right now thing,

813
00:52:59.940 --> 00:53:00.440
to

814
00:53:00.900 --> 00:53:07.494
I can't remember when the couponing you don't have to add a coupon, but I don't remember when that special offer expires, but it's usually just a couple of days.

815
00:53:07.875 --> 00:53:10.535
Okay. Any other medical conditions inadvertently

816
00:53:10.915 --> 00:53:14.535
seem to be positively affected by cardigenics other than the gut?

817
00:53:17.010 --> 00:53:23.190
So the gut, any sort of physical injury, we've also seen some improvements with skin issues.

818
00:53:24.210 --> 00:53:29.350
So people who have inflamed skin, so whether you have dermatitis or some other form of inflamed skin,

819
00:53:30.055 --> 00:53:32.775
again, systemic inflammation plays a role in those.

820
00:53:32.775 --> 00:53:35.755
So with with with those, we've seen some improvements as well.

821
00:53:36.135 --> 00:53:36.635
Okay.

822
00:53:37.575 --> 00:53:43.035
Alex, I have OA, RA, and hypertension. I wanna take all three of Caloroid's products. I take

823
00:53:43.560 --> 00:53:44.060
amlodipine.

824
00:53:44.680 --> 00:53:45.820
Are there any contraindications?

825
00:53:47.720 --> 00:53:50.280
Yeah. I mean, I would I would definitely talk to your doctor about that.

826
00:53:50.280 --> 00:53:53.740
There's no I I don't see any reason why there would be a contraindication.

827
00:53:54.280 --> 00:53:56.700
The Vasconox is amazing for hypertension.

828
00:53:57.000 --> 00:54:01.505
Doctor Mark Houston, who runs the Hypertension Institute has done the studies on it.

829
00:54:01.744 --> 00:54:08.645
And keep in mind, VASCO Nox, why it's the nitric oxide version I take, it's the only nitric oxide product that maintains

830
00:54:09.025 --> 00:54:12.805
functional levels of nitric oxide in your blood for twenty four hours.

831
00:54:13.190 --> 00:54:23.370
All of the nitric nitric oxide products that have nitrate nitrites, what they do is they give you a spike of nitric oxide, over a couple hours, and then it drops down below functional levels.

832
00:54:23.990 --> 00:54:29.955
This is the only product that maintains functional levels for twenty four hours, so it's a very effective product.

833
00:54:29.955 --> 00:54:31.415
So, yeah, you're you're perfectly,

834
00:54:31.955 --> 00:54:34.535
right to take both of them. Can I give it to my dog?

835
00:54:35.475 --> 00:54:37.155
The cardigenics, yes. You can.

836
00:54:37.155 --> 00:54:46.280
So in fact, the the technology was originally developed for animals, for large breed animals and large breed dogs, and then it was adapted to humans and then the human studies were done.

837
00:54:46.280 --> 00:54:47.640
So perfectly safe for dogs.

838
00:54:47.640 --> 00:54:53.560
I don't know what MSRP is, Ken, other than manufacturer suggested retail price. So but there you go.

839
00:54:53.560 --> 00:54:54.700
Do you ship to Canada?

840
00:54:56.760 --> 00:55:02.225
I believe it is registered in Canada. One of the Calroy team can confirm, but I believe type that.

841
00:55:02.365 --> 00:55:04.625
Yeah. What if you already have a joint replacement?

842
00:55:05.005 --> 00:55:09.185
No problem. No problem. Because you still have soft tissue in the area. Right?

843
00:55:09.645 --> 00:55:11.505
How could it maybe help neuropathy?

844
00:55:12.869 --> 00:55:14.650
We we don't have any data on neuropathy.

845
00:55:15.109 --> 00:55:19.369
Right. One one thing that I do know helps neuropathy a lot is vitamin k two seven.

846
00:55:19.430 --> 00:55:21.589
We actually publish at Microbiome Labs.

847
00:55:21.589 --> 00:55:24.970
We're we're done and publish a couple different studies on that. Okay.

848
00:55:25.944 --> 00:55:29.325
K two seven. Okay. And is that in a Microbiome Labs product?

849
00:55:29.625 --> 00:55:32.525
It is. Yeah. They call it, we used to call it menaquinone

850
00:55:32.825 --> 00:55:35.625
or, megaquinone, I think it's called. Megaquinone. Right. Yeah.

851
00:55:35.625 --> 00:55:39.005
And you want three hundred micrograms or higher of k two seven.

852
00:55:39.385 --> 00:55:39.635
So,

853
00:55:41.880 --> 00:55:45.880
BJ Goldman, please tell us about Calroy. What is Karen's connection to Calroy?

854
00:55:45.880 --> 00:55:49.660
And then we are wrapping up. Yeah. So Calroy is an amazing,

855
00:55:49.960 --> 00:55:54.619
health care practitioner focused company. They are the pioneers on something called the glycocalyx,

856
00:55:55.255 --> 00:56:00.155
which is the matrix, the lining of the inner part of the vessels, and then there's other glycocalyx

857
00:56:00.695 --> 00:56:05.994
in the body as well. I got to know, some of the cofounders of Calroy over the last several years,

858
00:56:06.455 --> 00:56:09.035
and then I decided to partner with them on this cartogenics

859
00:56:09.335 --> 00:56:11.330
technology because it fits so

860
00:56:11.710 --> 00:56:14.450
well within their wheelhouse and what they do really well.

861
00:56:15.310 --> 00:56:20.610
So my relationship with them is, you know, as a partner with this product bringing it to marketplace.

862
00:56:20.990 --> 00:56:23.570
Okay. And do they ship to The UK? So

863
00:56:24.005 --> 00:56:26.585
someone from the Callroy team can go ahead,

864
00:56:27.685 --> 00:56:31.305
and answer Pam there. That would be great. Okay.

865
00:56:32.085 --> 00:56:37.045
I love you all. Thank you, Karen. I love you so much. Thank you. Thank you. Thank you.

866
00:56:37.045 --> 00:56:42.369
This is so exciting. I hope you all will try it. You have nothing to

867
00:56:42.750 --> 00:56:45.390
lose. You have ninety days. As soon as you get home, start.

868
00:56:45.390 --> 00:56:49.230
Like, don't do it, like, forty five days later and be like, yeah. You know? I don't know.

869
00:56:49.230 --> 00:56:51.150
I mean, because it may take you that long.

870
00:56:51.150 --> 00:56:55.815
On the other hand, you heard the results of people, and everyone will have their own result, of course.

871
00:56:55.815 --> 00:56:59.995
But I'm very excited about what you're doing, Karen, with the

872
00:57:00.855 --> 00:57:01.355
development

873
00:57:01.735 --> 00:57:02.235
of

874
00:57:02.935 --> 00:57:07.881
herbs in a different way. So it's it's it's very, very exciting.

875
00:57:07.881 --> 00:57:09.901
So thank you for your continued work.

876
00:57:11.801 --> 00:57:12.441
It is,

877
00:57:12.841 --> 00:57:16.826
it's super helpful. We love you. My pleasure. Thank you, everyone. Thanks for having me.